Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts
نویسندگان
چکیده
منابع مشابه
Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy.
We examined the role that enzymatic protein O-GlcNAcylation plays in the development of diabetic cardiomyopathy in a mouse model of Type 2 diabetes mellitus (DM2). Mice injected with low-dose streptozotocin and fed a high-fat diet developed mild hyperglycemia and obesity consistent with DM2. Studies were performed from 1 to 6 mo after initiating the DM2 protocol. After 1 mo, DM2 mice showed inc...
متن کاملUnsticking the Broken Diabetic Heart: O-GlcNAcylation and Calcium Sensitivity
Cardiovascular disease is the leading cause of death in patients with diabetes. However, identifying mechanisms of disease progression has proven difficult as diabetes involves dysfunction of numerous pathways including cellular signaling and mitochondrial capacity. This results in the alteration of circulating hormones and nutrients that can lead to inflammation, oxidative stress, endoplasmic ...
متن کاملComparative mitochondrial proteomics: perspective in human diseases
Mitochondria are the most complex and the most important organelles of eukaryotic cells, which are involved in many cellular processes, including energy metabolism, apoptosis, and aging. And mitochondria have been identified as the "hot spot" by researchers for exploring relevant associated dysfunctions in many fields. The emergence of comparative proteomics enables us to have a close look at t...
متن کاملMemory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
O-GlcNAcylated proteins are abundant in the brain and are associated with neuronal functions and neurodegenerative diseases. Although several studies have reported the effects of aberrant regulation of O-GlcNAcylation on brain function, the roles of O-GlcNAcylation in synaptic function remain unclear. To understand the effect of aberrant O-GlcNAcylation on the brain, we used Oga+/- mice which h...
متن کاملNucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins
O-linked N-acetylglucosamine modification (O-GlcNAcylation) is a nutrient-dependent protein post-translational modification (PTM), dynamically and reversibly driven by two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) that catalyse the addition and the removal of the O-GlcNAc moieties to/from serine and threonine residues of target proteins respectively. Increasing evidence suggests...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2016
ISSN: 1535-3893,1535-3907
DOI: 10.1021/acs.jproteome.6b00250